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Korean J Urol Oncol > Volume 3(2); 2005 > Article
The Korean Journal of Urological Oncology 2005;3(2): 86-91.
방광암의 진단과 추적관찰에 있어서 요ThinPrep 검사의 유용성
박성훈, 오경진, 황인상, 강택원, 권동득, 박광성, 류수방
전남대학교 의과대학 비뇨기과학교실
Availability of the Urine ThinPrep Test in the Diagnosis and Follow Up of Bladder Cancer
Sung Hun Park , Kyung Jin Oh , In Sang Hwnag , Taek Won Kang , Dong Deuk Kwon , Kwangsung Park , Soo Bang Ryu
Department of Urology, Chonnam National University Medical School, Gwangju, Korea
Published online: December 1, 2005.
ABSTRACT
Purpose:
Although urine cytology has been used as a useful diagnostic and follow up test for bladder cancer, it has limitations in diagnosing low grade and superficial bladder cancer. This study was aimed to compare the availability of urine ThinPreptest, a recently introduced noninvasive test, and conventional urine cytology for assessing the diagnosis and follow up of bladder cancer.
Materials and Methods:
Between January 2003 and June 2004, urine samples of 259 patients were underwent urine ThinPreptest and conventional urine cytology. As a results of two diagnostic tests, we classified benign (negative and benign atypia), malignant(suspicious and transitional cell carcinoma), and compared sensitivity and specificity of two tests with postoperative biopsy reports.
Results:
Considering all features of both urine ThinPreptest and urine cytology reviewed, the overall quality of slides of two tests was comparable in the majority of cases. In total 259, the overall sensitivity of the urine ThinPreptest was 78.9% versus 55.3% for urine cytology. In 38 cases, bladder tumors were detected and identified was transitional cell carcinoma by histologic exam. According to postoperatvie biopsy reports, in both groups, suspicious bladder tumor group and follow up of transurethral resection of bladder tumor group, urin ThinPreptest gave higher increase in the sensitivity than for urine cytology test. Also, the sensitivity of urine ThinPrep test is more increased in low grade and low stage than high grade and high stage bladder tumor.
Conclusions:
The urine ThinPreptest has a benefit of high sensitivity in low grade, low stage bladder cancer. In conclusion, the urine ThinPreptest is a useful adjunct tool for the diagnosis and followup of patients with superficial bladder cancer. (Korean J Uro-Oncol 2005;3:86-91)
Key Words: Bladder neoplasms; Urine; Cytology
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