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Korean J Urol Oncol > Volume 19(4); 2021 > Article
Kim, Ye, Kim, Kim, Lee, Byun, and Oh: Perioperative Outcomes of Different Surgical Methods Among Bladder Cancer Patients Undergoing Radical Cystectomy With Neobladder Urinary Diversion

Abstract

Purpose

To compare perioperative outcomes according to surgical methods among bladder cancer patients who underwent radical cystectomy (RC) with neobladder urinary diversion.

Materials and Methods

Between June 2007 and January 2020, 89 bladder cancer patients who received RC with neobladder urinary diversion were enrolled in this study. Patients were stratified into surgical methods – (1) open RC with neobladder (ONB) reconstruction, (2) robot-assisted RC (RARC) with extracorporeal neobladder (ECNB) reconstruction, and (3) RARC with intracorporeal neobladder (ICNB) reconstruction. Perioperative outcomes were compared among the 3 groups, with major complications defined according to Clavien-Dindo grades III– V within 90 days. Logistic regression analysis was performed to identify significant factors for postoperative complications.

Results

Of 89 patients, 28 (31%) had ONB, 31 (35%) had ECNB, and 30 (34%) had ICNB. The median operative time was 471 minutes, and the ICNB group (424.5 minutes) was significantly less than ONB (444.5 minutes) and ECNB groups (542.9 minutes) (p=0.001). Transfusion rate was also significantly less in the ICNB group (13%) (p=0.001). Complications were recorded in 67 patients (75%) and major complications in 22 of all patients (25%). The major complication rate was significantly less in ICNB (13.4%) than in ONB (25%) and ECNB (35%) (p=0.003). Multivariate analysis showed surgical methods (ICNB) (odds ratio [OR], 0.709; p=0.003) and age (OR, 1.150; p=0.001) were significant factors related to occurrence of major postoperative complications.

Conclusions

RARC with ICNB reduces postoperative complications compared to ONB and ECNB.

INTRODUCTION

Radical cystectomy (RC) with extended lympha- denectomy is a standard treatment method for muscle-invasive bladder cancer (MIBC) and high- risk nonmuscle-invasive bladder cancer (NMIBC).1 Since RC became the standard approach for treatment, we have been begun performing RC, we have been trying to reduce complications such as bleeding, facilitate quicker patient recovery. Also, extremely important have been attempts to improve patient satisfaction and quality of life after surgery. As a result, the rate of robot-assisted RC (RARC) has increased in recent decades.2 RARC and open RC have been shown to have no difference in oncologic outcomes.36 Although still somewhat controversial,3,7 recent large meta-analysis studies have shown that RARC outperforms open RC in functional outcome.8 With that in mind, we continue to try to reduce the incision size, and have tried various approaches to completing surgeries with minimal invasiveness.9,10 The current intracorporeal urinary diversion (ICUD) is the result of these efforts. In addition, there have been developments in orthotopic neobladder reconstruction which allows patients to void urine in a similar way to normal and to not require urostomy. There has been controversial for the optimal form of urinary diversion following RC. According to some recent studies, orthotopic neobladder and ileal conduit after RC show similar results in terms of global health status including some data with a better health-related quality of life in urinary outcomes.1113 However, orthotopic neobladder reconstruction patients had significantly better physical function, and were able to pursue a more active life-style than ileal conduit patients. These patients attained urethral voiding with good continence.14,15 Several studies have demonstrated that ileal neobladder urinary diversion is a safe procedure with perioperative and long-term morbidity comparable to ileal conduit diversion.16 And several studies have also demonstrated that orthotopic neobladder reconstruction has advantages for the patient's physical function over ileal conduit diversion.17
Several studies have compared ICUD and extra- corporeal urinary diversion (ECUD).1820 To date however, most studies comparing ICUD and ECUD at RARC have been done with a combination of neobladder and ileal conduit. There are also no studies comparing ONB with ECNB and ICNB respectively. RC with NB is essentially a treatment for bladder cancer, but at the same time, it builds a new urination system for patients. Therefore, maintaining a postoperative patient's quality of life similar to that enjoyed before surgery is also a very important goal of this operation. In that sense, it is extremely important to reduce the occurrence of postoperative complications which significantly degrade quality of life after surgery. Patients with even a single complication are often subject to frequent visits to hospitals and further hospitalizations.
The goal of the study, therefore, was to find out how much the ICNB reduces patient complications, by comparing it with more invasive surgeries. We compared perioperative outcomes and complications of ONB and ECNB and ICNB for bladder cancer. Although these 3 all have the same goal, there is a difference in approach such that ONB is open-ended to all surgical procedures, ECNB is open to bowel manipulation and neobladder formations, and ICNB is robotized to all surgical procedures. That order correlates with a progression to lesser invasion. Comparing and analyzing these 3 surgical techniques for postoperative complications is a way of directly identifying the effects of minimizing invasive surgery.

MATERIALS AND METHODS

From June 2007 to January 2020, we conducted a retrospective review of 89 patients who received RC with neobladder diversion from our institute for bladder cancer. The patients involved had MIBC (T2-T4aN0M0) or high-risk NMIBC (Ta, Tis, T1). All of them had received at least 3 months of follow-up and had previously signed the informed consent. In all cases extended lymphadenectomy was performed. The extent of pelvic lymph node dissection was determined at the discretion of surgeons based on clinical preferences and judg- ments (based on the extent of disease, vascular disease). Males had the prostate removed.
The data were collected for all RC with neobla- dder patients conducted by a single institution over a period of 14 years. ONB was performed by 3 experienced surgeons at a single institution, but 61 cases of RARC with NB were performed by one surgeon. The data included patient demographics (age, gender, body mass index), scores, marks, neoadjuvant chemotherapy, previous radiotherapy, previous abdominal surgery, hydronephrosis, surgical time (minute), estimated blood loss, and transfused units (if any), postoperative complications based on the modified Clavien-Dindo classification system, length of stay, reoperations, readmissions, interventional radiology procedures, number of resected lymph nodes, and pathologic stage.
Postoperative complications occurring during the first 90 days after the intervention were included, and these were classified as minor (Clavien-Dindo I– II) and major (Clavien-Dindo III– V). Follow-up was performed at 3, 6, and 12 months after surgery, and annually thereafter by physical examination, blood test, and abdominal computed tomography scan.
Patients were divided into 3 groups to compare and analyze preoperative clinical and pathological characteristics and postoperative complications. One-way analysis of variance was used to compare continuous variables, and chi-square test was used to compare categorical variables. Multivariable binary logistic regression was conducted to find complication predictors focused on overall complication rates in ICNB versus ECNB and ONB. All statistical analyses were performed using the IBM SPSS Statistics ver. 19.0 (IBM Co., Armonk, NY, USA); all p-values were presented as 2-sided; p-values <0.05 were considered to be statistically significant.
The present study permitted by Institutional Review Board (IRB No. B-2005-613-114) of Seoul National University Bundang Hospital.

RESULTS

Table 1 shows preoperative clinical and patho- logical characteristics of patients undergoing open RC with neobladder and RC with ECNB and ICNB. The average age of the ONB group at 56.8 years, was lower than that of the other 2 groups (p=0.004) and the American Society of Anesthesiologists (ASA) physical status was also better overall than the other groups (p=0.005). Preoperative hemoglobin was higher at 14.02 in the ONB group compared to the other groups (p=0.001). The ECNB was 13.4 and the ICNB was 12. There were only 3 patients receiving ONB who received neoadjuvant chemotherapy, which was less than the other groups.
Table 1.
Preoperative clinical and pathological characteristics of patients undergoing radical cystectomy with neobladder
Characteristic Total series (n=89) ONB (n=28) ECNB (n=31) ICNB (n=30) p-value
Mean age (yr) 61.48 56.78 62.25 65.06 0.004
Sex         0.094
 Male 82 (92) 28 (100) 26 (84) 27 (90)  
 Female 7 (8) 0 (0) 5 (16) 3 (10)  
Mean BMI (kg/m2) 25.09 24.21 25.52 25.48 0.234
Prior abdominal and/or pelvic surgery 18 (20) 7 (25) 8 (26) 4 (13) 0.505
Prior neoadjuvant chemotherapy 24 (30) 3 (11) 12 (39) 17 (57) 0.001
Smoking history         0.528
 Never smoker 26 (29) 15 (54) 8 (26) 3 (10)  
 Ever smoker 63 (71) 13 (46) 23 (61) 27 (90)  
ASA PS classification         0.005
 I 28 (31) 15 (54) 10 (32) 5 (17)  
 II 43 (48) 13 (46) 19 (61) 18 (60)  
 III 6 (67) 0 (0) 2 (7) 7 (23)  
Preoperative hemoglobin 13.11 14.02 13.45 12.03 0.001
TUR pT         0.753
 pTx-pTa-T1-Tis 27 (30) 10 (36) 7 (23) 10 (33)  
 T2-T4a 50 (56) 18 (64) 19 (61) 13 (43)  
Pathologic stage         0.897
 T2 or less 64 (72) 21 (75) 23 (74) 20 (67)  
 T3 20 (22) 6 (21) 6 (19) 8 (27)  
 T4 5 (6) 1 (4) 2 (6) 2 (7)  
Mean no. of resected nodes 23.9 24.7 21.3 26.0 0.488
Positive surgical margins 0 (0) 0 (0) 0 (0) 0 (0)  

Values are presented as number (%) unless otherwise indicated.

ONB: open radical cystectomy with neobladder, ECNB: extracorporeal neobladder, ICNB: intracorporeal neobladder, ASA PS: American Society of Anesthesiologists physical status, TUR: transurethral resection of bladder tumor.

p<0.05, statistically significant differences.

Table 2 shows the perioperative outcomes and complications of patients undergoing ONB, ECNB, and ICNB. The average surgical time was significantly longer for the ECNB group at (542.9 minutes; p=0.001) among the 3 groups. The average hospitalization period was 31 days in the ONB group, 20.7 days in the ECNB group, and 15.5 days in the ICNB group, significantly longer in the ONB group, and shorter in the ICNB group.
Table 2.
Perioperative outcomes and complications of patients undergoing RC with NB
Variable Total series (n=89) ONB (n=28) ECNB (n=31) ICNB (n=30) p-value
Median operative time (min) 471 444.5 542.9 424.5 0.001
Mean hospital stay (day) 22 31 20.7 15.5 0.001
Hospital readmission 34 (38) 12 (43) 16 (52) 6 (20) 0.003
Intraoperative transfusion of RBC 26 (29) 17 (60) 5 (17) 4 (13) 0.001
Postoperative complication 67 (75) 23 (82) 25 (80) 19 (63) 0.046
 Gastrointestinal 11 (12) 5 (18) 6 (19) 0 (0) 0.041
 Hematological 32 (36) 14 (50) 10 (40) 8 (27) 0.157
 Genitourinary 25 (26) 5 (18) 12 (39) 8 (27) 0.126
 Cardiovascular 1 (1) 1 (4) 0 (0) 0 (0) 0.332
 Pulmonary 2 (2) 1 (4) 0 (0) 2 (7) 0.578
 Infection 34 (38) 10 (36) 16 (52) 8 (27) 0.127
 Wound 14 (16) 7 (25) 5 (16) 2 (7) 0.159
 Neurological 1 (1) 0 (0) 0 (0) 1 (3) 0.37
 Vascular 0 (0) 0 (0) 0 (0) 0 (0)  
 Total complications 118 43 49 29  
Clavien-Dindo classification         0.003
 0 22 (25) 5 (18) 6 (19) 11 (37)  
 I–II 45 (51) 16 (57) 14 (45) 15 (50)  
 III–IV 22 (25) 7 (25) 11 (35) 4 (13)  

Values are presented as number (%) unless otherwise indicated.

RC: radical cystectomy, NB: neobladder, ONB: open radical cystectomy with NB, ECNB: extracorporeal NB, ICNB: intracorporeal NB, RBC: red blood cell.

p<0.05, statistically significant differences.

Blood transfusion rates in the 3 groups were 60% in ONB, 17% in ECNB, and 13% in ICNB, which was significantly higher in the ONB group (p=0.001). There was no open conversion in ECNB and ICNB groups. At least one postoperative complication occurred in 67 patients (75%) of all 3 groups. Postoperative complications occurred in 23 (82%) receiving ONB, 25 (80%) receiving ECNB, and 19 (63%) receiving ICNB, a significantly lower incidence of complications in ICNB (p=0.046). In particular, there were 7 major complications (25%) (Clavien-Dindo III– IV) in the ONB group and 11 (35%) in ECNB group, but only 4 (13%) in the ICNB group, a significantly lower incidence of complications in ICNB (p=0.003). The most common complications were infection (38%) and hematological complication (32%), followed by genitourinary complication (26%), wound problem (16%), and gastrointestinal complication (12%). Most of the major complications were treated by PCN inserts or double J stent inserts due to hypdronephrosis after surgery, a total of 9 patients (10%). There were 7 cases (8%) of reoperation under general anesthesia, and 2 of them required transurethral resection of bladder neck surgery due to urethral stricture. There were also 2 surgeries to switch back from neobladder to ileal conduit. There were 3 people who perfor- med a wound repair under anesthesia due to a wound complication, and 3 others performed percutaneous drainage insertion with urine leakage or formula formation. No positive surgical margins were recorded among the 3 groups.
Table 3 shows multivariable analyses of predictors of postoperative complications (Clavien-Dindo III– IV). Here, we analyzed ONB and ECNB as one group, and show that ICNB had less complications than the other combined group (odds ratio, 0.709; p=0.003). Covariates include age and intraoperative transfusion of red blood cell. In addition to surgi- cal techniques, age was also associated with com- plications.
Table 3.
Multivariable analyses of predictors of postoperative major complications (Clavien-Dindo III or IV)
Variable Univariable analysis Multivariable analysis
OR (95% CI) p-value OR (95% CI) p-value
Age (yr) 1.102 (1.028–1.181) 0.006 1.150 (1.059–1.249) 0.001
Body mass index (kg/m2) 0.998 (0.858–1.162) 0.983    
Gender        
 Male (reference) 1      
 Female 2.259 (0.490–10.411) 0.296    
Prior abdominal and/or pelvic surgery 1.434 (0.428–4.803) 0.559    
Prior neoadjuvant chemotherapy 0.482 (0.152–1.530) 0.216    
OP method        
 ONB+ECNB 1   1  
 ICNB 0.763 (0.635–1.357) 0.021 0.709 (0.416–1.061) 0.003
Intraoperative transfusion of RBC 5.893 (2.022–17.177) 0.001 1.014 (0.301–3.420) 0.982
Operating time 1.002 (0.998–1.007) 0.335    
Preoperative hemoglobin 1.123 (0.864–1.459) 0.385    
ASA PS classification        
 I or II (reference) 1      
 III or IV 1.530 (0.585–4.025) 0.385    

OR: odds ratio, CI: confidence interval, OP: operation, ONB: open radical cystectomy with neobladder, ECNB: extracorporeal neobladder, ICNB: intracorporeal neobladder, RBC: red blood cell, ASA PS: American Society of Anesthesiologists physical status.

p<0.05, statistically significant differences.

DISCUSSION

In this study, ICNB produced fewer major com- plications than ONB and ECNB. In particular, there were no significant differences in compli- cations between ONB and ECNB except for the transfusion rate. It can be assumed that most of the complications are caused by manipulation of the bowel. In this regard, Kang's early experience of RARC with total ICUD in a paper that researched ICUD, explained that it reduces bowel exposure and has the advantage of maintaining the humidity of the bowel thus reducing the potential for fluid imbalances.21 It can be assumed that our findings also reflect that. Most of the major complications in these reports were related to urinary diversion. On the other hand, the RC part was safer and more feasible.
Our findings are also similar to those reported by Carrion et al.22 They reported that ICUD was associated with lower complication rates compared to ECUD. In their report, patients who underwent ECUD had a higher rate of uretero- ileal strictures than those with ICUD (45.5% vs. 14.3%, p=0.026). Among the neobladders, ECUD developed a higher rate of urethro-neobladder stricture than ICUD (33% vs. 0%, p=0.044).
Conversely, Mistretta et al.23 reported that there was no statistically significant difference between ICNB versus ECNB overall (ICNB: 75.4% vs. ECNB: 72.7%; p=0.9), or for major complications (ICNB: 28.1% vs. ECNB: 25%, p=0.6). Their work was most similar to ours in that they compared only in neobladder, and the number of patients was also slightly higher (ICNB: 57, ECNB: 44) than in the present study. However, in their study, the major complications rate of ICNB was 28%. This was much higher than we observed. Robot surgery techniques in the study of Mistretta et al.23 may not yet have been fully mature, or the difference may be due to other limitations of the study to be described below. Our research did not just compare ECNB and ICNB, but added ONB cases, which in total led to a larger number of patients than the study of Mistretta et al.23 Our study has added significance due to the analysis and comparison of each of the following surgical approaches: ONB that are completely open, ECNB that are partially done by robots, and ICNB that are totally done by robots.
In our study, ONB was performed by several surgeons but, all of the patients who underwent RARC with NB were performed by one surgeon, and due to this, we have removed or reduced variables that would have come from differences in surgical procedure details, that could have been present if there were other surgeons.
Table 1 shows the distribution of each group was not even. If only ECNB and ICNB are analyzed and compared, there is no difference between the 2 groups, but there is a difference if the 3 groups including ONB are analyzed. In particular, the group of patients who had ONB were younger so preoperative hemoglobin was high and ASA was good. There is less neoadjuvant chemotherapy. Most ONB patients had RC before 2015, whereas most RARC patients underwent surgery after 2015. This may be part of the explanation. The criteria for patient selection and surgical indication have also changed somewhat over the past 15 years, but the average age of Koreans has risen, and the number of patients coming to our hospital has changed. In the area where our hospital is located, aging of the population has progressed more rapidly than other regions over the past decade.
The 3 surgeries showed a significant difference in operating time. Compared to other groups, the operative time is much longer in the ECNB group and the inclusion of the time to de-dock the robot in the middle may have influenced this.
The duration of the hospital stay was signifi- cantly higher with ONB. Although the recovery of ONB patients was slower, the main impact on duration is likely to be the relatively more recent emphasis on early discharge, so it is believed that this may explain the result. Currently, if complications do not occur and the recovery is successful, all RARC patients are discharged around 14 days. A similar explanation may apply as to why the readmission rate within 90 days is high in the ECNB group. The 17 patients who were readmitted in both groups required management due to complications that occurred after the operation.
In the 3 groups, 24% of patients had transfusions during the operation. Of these, 60% received ONB while 17% and 13% had ECNB and ICNB respectively. ONB clearly resulted in more bleeding during surgery.
Fewer postoperative complications occurred in the ICNB group and the difference was greater for major complications. The most common com- plications were infection (38%) and hematological complication (32%), followed by genitourinary complication (26%), wound problem (16%), and gastrointestinal complication (12%). Since an infection focus is not always found, this complication includes patients who start on antibiotics with unknown cause of fever, and therefore may be overestimated. Hematological complication includes all cases of blood trans- fusion during surgery or within 90 days of surgery, so this may also have been overestimated. There were 5 gastrointestinal complications in ONB, 6 in ECNB, and none in ICNB. This finding supports the hypothesis that ICUD techniques reduce fluid loss from the bowel and minimize trauma and consequent edema to the barrier, thereby lowering gastrointestinal complications. The intervention due to hydronephrosis occurred only in the ONB and ECNB groups, and ICNB had none. Similarly, no interventions due to urethral stricture occurred in ICNB. This is consistent with the assumption that robot-assisted anastomosis of neobladder and urethra will be simplified compared to the process of externalization of the neobladder and later reinitiation of the pneumoperitoneum. As well it can be assumed that ICNB will cause less damage to tissues such as neobladder and urethra, among others.
The reported results demonstrate the potential benefits of ICNB, which is consistent with the hypothesis set in the early stages of the study. These benefits include reduced bleeding, reduced blood transfusion requirements, and shorter hospitalization. The results of the current series show that ICNB following RARC is feasible, safe, and excellent from a complications perspective. In particular, the fact that only 4 major complications occurred with the ICNB group further reinforces this hypothesis. Overall, we have confirmed once again that developing techniques that enhance minimal invasiveness is a critical part of a surgeon's role.
Following are the limitations of this study. (1) The study was conducted retrospectively and non- randomly in a single center, and the number of patients is small. And, almost RARC cases were carried out by the same surgeon. In addition, the surgeon performed all ECNB cases first, followed by all ICNB surgical cases. It was highly likely that the learning curve had an effect. Thus, some effort was made to correct the learning curve from the design stage of the study. When comparing the incidence of complications by year, the difference was not significant by year. Surgeon was enough familiar with robot handling techniques from the start, so the learning curve may not have been as large as expected. Nevertheless, the learning curve due to the difference in the timing of ECNB and ICNB will be reflected to some extent, and it is thought to be an important limitation of this study. (2) Most ONB was done much earlier compared to RARC. This difference led to differences in the distribution between each group which was uneven in the analysis of preoperative clinical characteristics of patients and the management of patients. As a result, not only surgical techniques but also postoperative patient care techniques have varied over time, which may have affected the results of this analysis. However, the neobladder formation techniques on ONB and ECNB were the same. This makes this study more convincing. And in terms of the preoperative condition of patients, the ONB group had the best patients, followed by ECNB and ICNB were worst. The differences in postoperative complications shown in this study are likely to be underestimated. (3) The advantages of the enhanced recovery after-surgical (ERAS) method have been known for years,2426 and as a result, most ONB patients have not been ERAS-applied, while most ICNB patients have been. It is, therefore, possible that this affected some of the outcomes. (4) The difference in the timing of the surgery also makes the difference in neoadjuvant chemotherapy rate between each group. Almost ONB surgery was performed in the past when neoadjuvant chemotherapy was not performed. It also seems to be an important limitation. (5) If the postoperative complications were divided into early and postmerger complications, another meaningful interpretation may have been found. Nevertheless, our work provides valuable data as the first comparison of ONB, ECNB, and ICNB. Studies will be needed in future which avoids the above limitations while adding oncologic outcomes.

CONCLUSIONS

Compared to other neobladder reconstruction methods, RARC with intracorporeal neobladder reconstruction reduces postoperative complications such as postoperative ileus, uretero-neobladder, and urethra-neobladder stricture during the follow-up period. It also reduces the duration of hospitalization after surgery and the rate of readmission after discharge. Overall, ICNB improves postoperative patient satisfaction.

Conflict of Interest

The authors claim no conflicts of interest.

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