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Korean J Urol Oncol > Volume 11(3); 2013 > Article
The Korean Journal of Urological Oncology 2013;11(3): 109-115.
비침윤성 방광암 치료에서 수술 전후 방광내 항암치료: 필요한가?
김 명, 구자현
서울대학교 의과대학 비뇨기과학교실
Peri-Operative Intravesical Chemotherapy in the Treatment of Non-Muscle Invasive Bladder Cancer: Is It Necessary?
Myong Kim , Ja Hyeon Ku
Department of Urology, Seoul National University College of Medicine, Seoul, Korea
Published online: December 30, 2013.
ABSTRACT
Peri-operative intravesical instillation of chemotherapy in non-muscle invasive bladder cancer (NMIBC) is one of the options for adjuvant therapy after the transurethral resection of bladder tumor (TURBT). Early instillation is known tosuppress the implantation of tumor cells. Meta-analysis of postoperative immediate instillation of chemotherapy showed that treatment reduced the risk of recurrence up to 39%. Most guidelines recommended the routine application of postoperative immediate instillation within 24 hours after the TURBT in the low- to intermediate-risk NMIBC. However, efficacy of postoperative immediate instillation of chemotherapy in the high-risk NMIBC has not been well established. Although numerous researches implied that postoperative immediate instillation maybe effective, recent randomized controlled trials could not prove it. Therefore, the role of postoperative immediate instillation in the high-risk NMIBC has not been confirmed, although some guidelines also recommend that procedure in this group. The well-designed, large-sized randomized controlled trials are needed to verify this issue. (Korean J Urol Oncol 2013;11:109-115)
Key Words: Urinary bladder neoplasms; Intravesical; Chemotherapy; Recurrence; Disease progression
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