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Korean J Urol Oncol > Volume 10(3); 2012 > Article
The Korean Journal of Urological Oncology 2012;10(3): 130-137.
RNASEL Gene Polymorphisms are Associated with PSA Level and Prostatic Volume in Korean Men with Benign Prostatic Hyperplasia
Hae Jong Kim 1,2, Jaehyouk Lee 1,2, In Ho Chang 1,4, Tae Hyoung Kim 1,4, Kyung Do Kim 1,4, Seok-Soo Byun 3, Soon Chul Myung 1,2,4
1Advanced Urogenital Disease Research Center, 2Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, 3Department of Urology, Seoul National University Bundang Hospital, Seongnam, 4Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea
Published online: December 30, 2012.
The precise etiology of benign prostatic hyperplasia (BPH) is not fully determined, however, it is known that inflammatory processes have a role in the pathogenesis of BPH initiation and progression. RNASEL at chromosome 1q25 encodes ribonuclease L, part of the interferon-mediated immune response to viral infection. The aim of study was to investigate the relationship between RNASEL polymorphisms and BPH.
Materials and Methods:
With a cohort of 173 BPH subjects, we genotyped ten single nucleotide polymorphisms (SNPs) in the RNASEL gene using Golden gate assay. The associations with PSA levels or prostatic volume among the BPH subjects were analyzed.
There were significant associations between three SNPs and low prostate-specific antigen groups (rs672527, rs10911099, rs12034888). One SNP (rs11072) was associated with prostatic volume. We detected a strong association in genotype frequencies of RNASEL SNP (rs672527) between subjects with high transitional volume.
The result suggests that RNASEL may be associated with PSA level and prostatic volume in BPH. (Korean J Urol Oncol 2012;10:130-137)
Key Words: Prostatic hyperplasia; 2-5A-dependent ribonuclease; Polymorphism
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