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Korean J Urol Oncol > Volume 10(1); 2012 > Article
The Korean Journal of Urological Oncology 2012;10(1): 13-20.
전립선 배아기상호유도작용 재활성의 원인 1: 만성 염증
정재동, 최세영, 이상협, 명순철
중앙대학교 의과대학 비뇨기과학교실
Etiology of Prostatic Reactivation of Embryonic Growth Pathways 1: Chronic Inflammation
Jae Dong Chung , Se Young Choi , Sang Hyup Lee , Soon Chul Myung
Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea
Published online: April 30, 2012.
ABSTRACT
Traditionally, androgens and ageing have been considered confirmative main factors of prostate enlargement. McNeal noted that the proliferation closely resembled developmental differentiation and posited that epithelial hyperplasia may be the result of reactivation of embryonic pathways. He postulated that the combined stromal and ductal hyperplasia in aging men resulted from a re-awakening of these mesenchymal-epithelial inductive interactions. Latest years, acute and chronic inflammation of the prostate and decreasing testosterone levels may important in the aging related re-awakening. So aim of this article is to provide a review of the role of chronic inflammation in benign prostate hyperplasia. (Korean J Urol Oncol 2012;10:13-20)
Key Words: Benign prostate hyperplasia; Chronic inflammation
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