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Korean J Urol Oncol > Volume 9(2); 2011 > Article
The Korean Journal of Urological Oncology 2011;9(2): 43-50.
유전적 요로상피종양, 부신 크롬친화세포종 및 고환 생식세포종양의 유전
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전남대학교 의과대학 비뇨기과학교실
Genetics of Hereditary Urothelial Cell Tumor, Adrenal Pheochromocytoma, and Testicular Germ Cell Tumor
Seung Il Jung
Department of Urology, School of Medicine, Chonnam National University, Gwangju, Korea
Published online: August 30, 2011.
ABSTRACT
A family history of malignancy has long been recognized as a risk factor for developing cancer. The increased risk can be due to either a shared genetic heritage or a shared environmental exposure. Identifying a hereditary predisposition to a particular malignancy has proven to be a powerful tool to identify genes responsible for not only hereditary tumor syndromes but also sporadic malignancies. The identification of the genes responsible for hereditary urologic tumors has illuminated the molecular cause of many sporadic malignancies and expanded our understanding of cancer. The present review considers the genetics of urothelial tumor, adrenal pheochromocytoma, and testicular germ cell tumor. (Korean J Urol Oncol 2011;9:43-50)
Key Words: Hereditary; Genetics; Transitional cell carcinoma; Pheochromocytoma; Testicular neoplasms
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