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Korean J Urol Oncol > Volume 5(2); 2007 > Article
The Korean Journal of Urological Oncology 2007;5(2): 92-96.
The Impact of Tumor-associated Symptoms on the Prognosis of Patients with Renal Cell Carcinoma: Multicenter Study
Kyung Seop Lee , Ki Ho Kim , Tae Gyun Kwon 1, Bup Wan Kim 1, Choal Hee Park 2, Chun Il Kim 2, Duk Yoon Kim 3, Jae Shin Park 3, Seong Ryung Jo 4, Hee Chang Jung 5, Tong Choon Park 5
Department of Urology, College of Medicine, Dongguk University, Gyeongju, 1Kyungpook National University, 2Keimyung University, 3The Daegu Catholic University, 4Fatima Hospital, 5Yeungnam University, Daegu, Korea
Published online: August 1, 2007.
ABSTRACT
Purpose:
Advanced imaging modalities have increased the frequency of incidentally found renal cell carcinoma (RCC). The aim of study was to investigate the prognostic differences between incidentally detected RCC and RCC with symptoms.
Materials and Methods:
343 patients who underwent radical or partial nephrectomy for treatment of RCC between January 1995 and December 2004 in 5 training hospitals were the subjects. Patients were classified into 2 groups according to the presence or absence of tumor associated symptoms. In order to compare patient's characteristics the chi-square and Student's t-test were performed. Comparison of survival was done by Kaplan-Meier (log rank test) method.
Results:
Of the 343 patients, 248 patients (72.3%) had no symptoms at the time of diagnosis (asymptomatic group) and 95 patients (27.7%) had symptoms at the time of diagnosis (symptomatic group). The patients' mean age (p=0.64), male-to-female ratio (p=0.42), nuclear grade (p=0.31) and cell morphology (p=0.34) were not significantly different in between two groups. However there were significant differences between two groups in terms of size of tumor (p<0.01), type of surgery (p=0.03) and tumor stage (p<0.01). Survival rate was better in asymptomatic group than in symptomatic group (p=0.01) with mean survival period of 95.5±4.4 and 81.0±6.1 months and 5-year survival rate of 82% and 62%, respectively.
Conclusions:
Incidentally detected RCC without symptoms at the time of diagnosis showed lower clinical stage in comparison with RCC with symptoms and are expected to show better prognosis accordingly. (Korean J Urol Oncol 2007;5:92-96)
Key Words: Renal cell carcinoma; Symptoms; Survival
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