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Korean J Urol Oncol > Volume 1(1); 2003 > Article
The Korean Journal of Urological Oncology 2003;1(1): 78-85.
방광 이행상피암종에서 E-cadherin과 β-catenin의 발현 및 유전자 돌연변이
오미혜, 임정화, 김영식, 김인선, 김한겸, 박홍석1, 천 준1, 조성진2
고려대학교 의과대학 병리학교실, 1비뇨기과학교실, 2한림대학교 의과대학 병리학교실
Expression and Mutation of E-cadherin and β-catenin in Transitional Cell Carcinoma of the Urinary Bladder
Mee-Hye Oh , Zhen Hua Lin , Young Sik Kim , Insun Kim , Han Kyeom Kim , Hong Suk Park1 , Jun Cheon1 , Seong Jin Cho2
Departments of Pathology and 1Urology, College of Medicine, Korea University and 2Department of Pathology, College of Medicine, Hallym University, Seoul, Korea
Published online: March 30, 2003.
ABSTRACT
" E-cadherin, a cell adhesion molecule that plays a diverse role in cell-cell interaction, and this adhesion is mediated by a group of cytoplasmic proteins, including the catenins that link the E-cadherin to the actin cytoskeleton. They are essential for maintaining epithelial intercellular adhesion and act particularly as a suppressor of invasive ability of cancer. To determine the potential prognostic values of E-cadherin and β-catenin, the correlation with the histologic grade, clinical stage, and tumor recurrence were evaluated and their expression and somatic mutation of 43 patients with transitional cell carcinoma of the urinary bladder. Abnormal immunohistochemical expression of E-cadherin and β-catenin was observed in 14 cases (33%) and 18 cases (42%), respectively of transional cell carcinomas and it was correlated with histologic grade and tumor depth and showed without significance lymph node metastasis. The mutation was seen in only 4 cases (9%) for E-cadherin and none for β-catenin. It was concluded assessment of E-cadherin and β-catenin immunoreactivity may be a useful prognostic factor in transitional cell carcinoma of urinary bladder, but their mutation seems to have a minor role in carcinogenesis."
Key Words: E-cadherin; β-catenin; Transitional cell carcinoma; Urinary bladder; Prognostic factor
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