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Korean J Urol Oncol > Volume 7(3); 2009 > Article
The Korean Journal of Urological Oncology 2009;7(3): 131-136.
The Impact of Obesity on the Clinicopathological Factors and Biochemical Recurrence after Radical Prostatectomy for the Patients with Prostate Cancer
Changhee Yoo 1, Jin Seon Cho 1, Cheryn Song 2, Seong Il Seo 3, Seok-Soo Byun 4, Tae Gyun Kwon 5, Hyung Jin Kim 6, Tae Young Jung 7, Byung Ha Chung 8, Tae-Kon Hwang 9, Kang Hyun Lee 10, Moon Kee Chung 11, Wun-Jae Kim 12, Jun Cheon 13, Sang Eun Lee 4, Young Deuk Choi 8, Hyun Moo Lee 3, Eunsik Lee 14, Hanjong Ahn 2, Han Yong Choi 3
Department of Urology, College of Medicine, 1Hallym University, Chuncheon, 2Ulsan University, Ulsan, 3Sungkyunkwan University, Suwon, 4Seoul National University, Bundang Hospital, Seongnam, 5Kyungpook National University, Daegu, 6Chonbuk National University, Jeonju, 7Seoul Veterans Hospital, 8Yonsei University, 9The Catholic University of Korea, Seoul, 10Urologic Oncology Clinic, National Cancer Center, Goyang, 11Pusan National University, Busan, 12Chungbuk National University, Cheongju, 13Korea University, 14Seoul National University, Seoul, Korea
Published online: December 1, 2009.
ABSTRACT
Purpose:
It is controversial that obesity affects the outcome of surgical treatment for the patients with prostate cancer. We investigated clinicopathological impact of body-mass index (BMI) in the patients with prostate cancer who underwent radical prostatectomy.
Materials and Methods:
From the 14 medical centers, 1,392 patients were evaluated. Mean preoperative serum prostate-specific antigen (sPSA) and BMI were 10.3ng/ml and 24.3kg/m2, respectively. The patients were classified into three groups by BMI: normal (BMI<23kg/m2), overweight (23kg/m2≤BMI<27.5kg/m2), and obese (BMI≥27.5kg/m2). We evaluated various clinicopathological factors, including preoperative sPSA, biopsy and pathological Gleason score, clinical and pathological T stage, and resection margin status, in the three BMI-groups. We also analyzed hazard ratio for biochemical failure according to BMI.
Results:
The proportions of the normal, overweight, and obese patients were 33.7%, 52.9%, and 13.4%, respectively. BMI was significantly negative correlation with sPSA (R=0.057, p=0.033). Among the preoperative factors, only biopsy Gleason score were significantly higher in the overweight and obese group than normal group (p=0.027). Pathological outcomes after radical prostatectomy in overweight and obese group were not different from those in normal group. Biochemical recurrence rate was also not affected by obesity. Biopsy and pathological Gleason score, preoperative sPSA, pathological stage, margin status, and D’Amico risk groups were significant risk factors for biochemical recurrence in univariate analysis.
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