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Korean J Urol Oncol > Volume 7(2); 2009 > Article
The Korean Journal of Urological Oncology 2009;7(2): 74-81.
경직장 전립샘 생검의 양성 및 악성에서 전립선암 관련 지표인자들에 대하여 무증상 만성염증이 미치는 영향
박창후, 김성진, 박창면, 김한권, 박종연
울산대학교 의과대학 강릉아산병원 비뇨기과학교실
The Influence of Prostate Chronic Inflammation on Parameters Related to Prostate Cancer in Asymptomatic Patients
Chang Hoo Park , Sung Jin Kim , Chang Myeon Park , Han Kwon Kim , Jong Yeon Park
Department of Urology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, Korea
Published online: August 1, 2009.
ABSTRACT
Purpose:
We examined the effect of asymptomatic chronic prostatitis on total PSA (tPSA), free PSA (fPSA), PSA density (PSAD) and the ratio of free-to-total prostate specific antigen (%fPSA). And we investigated an association between chronic prostatitis and prostate cancer to avoid unnecessary second prostate biopsies.
Materials and Methods:
Initial transrectal ultrasound-guided prostate biopsies from 143 patients with tPSA level of between 4 and 10ng/ml were performed. We evaluated them for the presence of cancer and presence, extent and aggressiveness of chronic inflammation. We correlated them with intial prostate related parameters.
Results:
Chronic inflammation was present in 44 (95.7%) of 46 prostate cancer cases and in 90 (92.8%) of 97 non-cancer cases. In inflammation group, no significant difference was found in tPSA levels between cancer group and non-cancer groups, but on PSAD levels, significant increase was found in cancer group compared with non cancer group (0.23 vs 0.30, p<0.001), fPSA (1.61 vs 0.75ng/ml, p=0.004) and %fPSA (25.10 vs 11.85, p=0.012) were decreased significantly. In both cancer and non-cancer groups, no signigicant differences were found in levels of prostate-related parameters between inflammation and non-inflammation groups. In both cancer and non-cancer groups, no signigicant changes were found in levels of prostate-related parameters according to extent and aggressiveness of inflammation.
Conclusions:
Chronic inflammation can be related to elevation of tPSA level and may be a risk factor for prostate adenocarcinoma. The cut-off values of prostate related parameters are helpful to distinguish the cancer presence. The histologic review of inflammation is not helpful to decrease the unnecessary second prostate-biopsy. (Korean J Urol Oncol 2009;7:74-81)
Key Words: Prostate biopsy; Prostate cancer; Inflammation; PSA
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